Design Optimization of Gas Generator Hybrid Propulsion Boosters

A methodology used in support of a study for NASA/MSFC to optimize the design of gas generator hybrid propulsion booster for uprating the National Space Transportation System (NSTS) is presented. The objective was to compare alternative configurations for this booster approach, optimizing each candidate concept on different bases, in order to develop data for a trade table on which a final decision was based. The methodology is capable of processing a large number of independent and dependent variables, adjusting the overall subsystems characteristics to arrive at a best compromise integrated design to meet various specific optimization criteria subject to selected constraints. For each system considered, a detailed weight statement was generated along with preliminary cost and reliability estimates

An analysis of the cost differences between an advertised and instore market basket by type and location of retail grocery firms in the Knoxville SMSA

The objectives of this study were (1) to determine the relative price image position by type of firm and by location in the Knoxville Standard Metropolitan Statistical Area as reflected through advertised prices, (2) to determine if the image projected through advertising reflects the true price position of the firm, and (3) to determine the degree of homogeneity of pricing practices within each type of firm, area and the giving of trading stamps. Two sets of data were obtained: an average instore market basket using shelf prices collected from March through June, 1971, and an aver-age advertised market basket collected using newspaper advertisements from January through June, 1971. The data were analyzed by least-squares regression with (0, 1) dummy variables to handle type of firm, location, and trading stamps. The parameters of the model show the average effect of type store, location, and the use of trading stamps on the cost of an advertised and instore market basket. To compare the two sets of parameters an F ratio was calculated. The method of least squares regression analysis using only categorical dummy variables was equivalent to using analysis of variance. The analysis showed type of store, location and trading stamps to be nonsignificant in explaining the cost of an advertised and instore market basket at the .05 level. The results of the analysis showed a 15 percent difference between the highest and lowest advertised market basket cost but only a 4.5 percent difference with the instore market basket. The F ratio calculated to compare the two sets of parameters showed the two sets of parameters to be signi-ficantly different at the .01 level. The low R2\u27s for the two sets of data indicated that the cells used in explaining the cost variation were not adequate and that indivi-dual firms within a type and area rather than the types of firms would be more effective in explaining the cost variation

Summary of booster propulsion/vehicle impact study results

Hydrogen, RP-1, propane, and methane were identified by propulsion technology studies as the most probable fuel candidates for the boost phase of future launch vehicles. The objective of this study was to determine the effects of booster engines using these fuels and coolant variations on representative future launch vehicles. An automated procedure for integrated launch vehicle, engine sizing, and design optimization was used to optimize two stage and single stage concepts for minimum dry weight. The two stage vehicles were unmanned and used a flyback booster and partially reusable orbiter. The single stage designs were fully reusable, manned flyback vehicles. Comparisons of these vehicle designs, showing the effects of using different fuels, as well as sensitivity and trending data, are presented. In addition, the automated design technique is described

Design Principle of Conjugated Polyelectrolytes to Make Them Water‐Soluble and Highly Emissive

The correlation between the molecular design of a conjugated polyelectrolyte (CPE) and its aggregated structure and the emissive properties in water is systematically investigated by means of UV–vis spectrometry, fluorescence spectroscopy, and scanning/transmission electron microscopy. Five different and rationally designed CPEs having carboxylic acid side chains are synthesized. All five conjugated polyelectrolytes are seemingly completely soluble in water in visual observation. However, their quantum yields are dramatically different, changing from 0.45 to 51.4%. Morphological analysis by electron microscopy combined with fluorescence spectrophotometry reveals that the CPEs form self‐assembled aggregates at the nanoscale depending on the nature of their side chains. The feature of the self‐assembled aggregates directly determines the emissive property of the CPEs. The nature and the length of the spacer between the carboxylic acid group and the CPE backbone have a strong influence on the quantum yield of the CPEs. Our study demonstrates that bulky and hydrophilic side chains and spacers are required to achieve complete water‐solubility and high quantum yield of CPEs in water, providing an important molecular design principle to develop functional CPEs. The correlation between the molecular design of conjugated polyelectrolytes (CPEs) and their solubility and emissive properties in water is systematically investigated by means of UV–vis and fluorescence spectroscopy and electron microscopy. Bulky and hydrophilic side chains and spacers are required to achieve complete water solubility and high quantum yield of CPEs in water, providing an important molecular design principle to develop functional CPEs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90088/1/1076_ftp.pd

Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era

Since the development of the Radiation Therapy Oncology Group-Recursive Partitioning Analysis (RTOG-RPA) risk classes for high-grade glioma, radiation therapy in combination with temozolomide (TMZ) has become standard care. While this combination has improved survival, the prognosis remains poor in the majority of patients. Therefore, strong interest in high-grade gliomas from basic research to clinical trials persists. We sought to evaluate whether the current RTOG-RPA retains prognostic significance in the TMZ era or alternatively, if modifications better prognosticate the optimal selection of patients with similar baseline prognosis for future clinical protocols. The records of 159 patients with newly-diagnosed glioblastoma (GBM, WHO grade IV) or anaplastic astrocytoma (AA, WHO grade III) were reviewed. Patients were treated with intensity-modulated radiation therapy (IMRT) and concurrent followed by adjuvant TMZ (n = 154) or adjuvant TMZ only (n = 5). The primary endpoint was overall survival. Three separate analyses were performed: (1) application of RTOG-RPA to the study cohort and calculation of subsequent survival curves, (2) fit a new tree model with the same predictors in RTOG-RPA, and (3) fit a new tree model with an expanded predictor set. All analyses used a regression tree analysis with a survival outcome fit to formulate new risk classes. Overall median survival was 14.9 months. Using the RTOG-RPA, the six classes retained their relative prognostic significance and overall ordering, with the corresponding survival distributions significantly different from each other (P < 0.01, χ2 statistic = 70). New recursive partitioning limited to the predictors in RTOG-RPA defined four risk groups based on Karnofsky Performance Status (KPS), histology, age, length of neurologic symptoms, and mental status. Analysis across the expanded predictors defined six risk classes, including the same five variables plus tumor location, tobacco use, and hospitalization during radiation therapy. Patients with excellent functional status, AA, and frontal lobe tumors had the best prognosis. For patients with newly-diagnosed high-grade gliomas, RTOG-RPA classes retained prognostic significance in patients treated with TMZ and IMRT. In contrast to RTOG-RPA, in our modified RPA model, KPS rather than age represented the initial split. New recursive partitioning identified potential modifications to RTOG-RPA that should be further explored with a larger data set

Medical education as mission

A response to Mark Crouch’s article The Propper College